Dr.-Ing. Sebastian Brandstäter

Professur für Computergestützte Simulation im Bauingenieurwesen
Gebäude 41/100, Zimmer 041/5117
+49 89 6004 4138
sebastian.brandstaeter@unibw.de

Dr.-Ing. Sebastian Brandstäter

 

Profiles

 Linkedin  Google Scholar   Orcid 
GitHub Github  Scopus

 Researchgate

Research Interests

  • Scientific Machine Learning
  • Inverse analysis & Bayesian Inference
  • Uncertainty Quantification
  • Global Sensitivity Analysis
  • Surrogate Modelling
  • Multi-Physics & Multi-Scale Modelling
  • Biomedical Engineering

Scientific Software Development

I am committed to open-source software and actively contribute to the following research frameworks:

  • QUEENS – A Python framework for solver-independent multi-query analyses of large-scale computational models. GitHub 
  • 4C – A comprehensive multi-physics simulation framework. GitHub

Please find an overview of my open-source contributions and activities on my GitHub profile GitHub.

 

Academic Career

04/2022 - Present Postdoctoral Researcher & Lecturer, Institute for Mathematics and Computer-Based Simulation, University of the Bundeswehr Munich, Germany
03/2021 - 12/2021 Research Associate at the Institute for Continuum and Material Mechanics, Hamburg University of Technology, Germany
08/2016 - 12/2021

Research Associate at the Institute for Computational Mechanics, Technical University of Munich, Germany
 

 

Publications

Preprints and Articles Submitted for Publication

    1. Henke*, M. S., Brandstaeter*, S., Fuchs, S. L., Aydin, R. C., Gizzi, A., Cyron, C. J. (2025): Electromechanical computational model of the human stomach. Preprint, submitted for publication, arXiv web-logo.png *These authors contributed equally.
    2. Biehler*, J., Nitzler*, J., Brandstaeter*, S., Dinkel, M., Gravemeier, V., Haeusel, L. J., Robalo Rei, G., Willmann, H., Wirthl, B.,  Wall, W. A. (2025): QUEENS: An Open-Source Python Framework for Solver-Independent Analyses of Large-Scale Computational Models. Preprint,  arXiv web-logo.png *These authors contributed equally.
    3. Sahin, T., Bonari, J.,  Brandstaeter, S., & Popp, A. (2025). Data-Driven Surrogate Modeling Techniques to Predict the Effective Contact Area of Rough Surface Contact Problems. Preprint, submitted for publication, arXiv web-logo.png 
Articles in Peer-Reviewed International Journals

    1. Wirthl B., Brandstaeter S., Nitzler J. Schrefler B.A., Wall W.A. (2023) Global sensitivity analysis based on Gaussian-process metamodelling for complex biomechanical problems. Int J Numer Meth Biomed Engng. 39(3):e3675. (DOI: 10.1002/cnm.3675)
    2. Willmann H., Nitzler J., Brandstaeter S., Wall W. A. (2022) Bayesian calibration of coupled computational mechanics models under uncertainty based on interface deformation. Adv. Model. and Simul. in Eng. Sci. 9(24). (DOI: 10.1186/s40323-022-00237-5)
    3. Brandstaeter S., Fuchs S.L., Biehler J., Aydin R.C., Wall W.A., Cyron C.J. (2021) Global sensitivity analysis of a homogenized constrained mixture model of arterial growth and remodeling. Journal of Elasticity. 145. 191–221. (DOI: 10.1007/s10659-021-09833-9)
    4. Kremheller, J., Brandstaeter, S., Schrefler, B.A., Wall W.A. (2021) Validation and parameter optimization of a hybrid embedded/homogenized solid tumor perfusion model. Int J Numer Meth Biomed Engng. 37(8). e3508. (DOI: 10.1002/cnm.3508)
    5. Brandstaeter S.*, Fuchs S.L.*, Aydin R.C., Cyron C.J. (2019) Mechanics of the Stomach: a Review of an Emerging Field of Biomechanics. GAMM-Mitteilungen. 42(3). e201900001. (DOI: 10.1002/gamm.201900001) (*co-first authorship)
    6. Brandstaeter S., Gizzi A., Fuchs S.L., Gebauer A.M., Aydin R.C., Cyron C.J. (2018) Computational model of gastric motility with active-strain electromechanics. Z Angew Math Mech. 98(12). 2177-2197. (DOI: 10.1002/zamm.201800166)
    7. Aydin R.C., Brandstaeter S., Braeu F.A., Steigenberger M., Marcus R.P., Nikolaou K., Notohamiprodjo M., Cyron C.J. (2017) Experimental characterization of the biaxial mechanical properties of porcine gastric tissue. Journal of the Mechanical Behavior of Biomedical Materials. 74. 499-506. (DOI: 10.1016/j.jmbbm.2017.07.028)
International Conference Contributions with Abstract
    1. Henke, M., Brandstaeter, S., Gizzi, A., Cyron, C. J.: Coupled Electromechanical Simulations of The Human Stomach, 30th Congress of the European Society of Biomechanics (ESB 2025 Congress), Zürich, Switzerland, July 6 - 9, 2025
    2. Brandstaeter, S., Maradni, B., Popp, A.: Probabilistic virtual sensing with Gaussian processes and physics-based models, 6th International Conference on Uncertainty Quantification in Computational Science and Engineering (UNCECOMP 2025), Rhodes, Greece, June 15 - 18, 2025.
    3. Brandstaeter S., Popp A.: Examining the Influence of Dependent Parameters on Biomechanical Models with Global Sensitivity Analysis, 9th European Congress on Computational Methods in Applied Science and Engineering, Lisbon, Portugal, June 3 - 7, 2024.
    4. Brandstaeter S., Popp A.: Global sensitivity analysis for biomechanical models with dependent input parameters, 94th Annual Meeting of the International Association of Applied Mathematics and Mechanics, Magdeburg, Germany, March 18 - 22, 2024.
    5. Brandstaeter S., Wirthl B., Nitzler J., Wall W. A.: Exploring biomechanical models with global sensitivity analysis. 10th GACM Colloquium on Computational Mechanics. Vienna, Austria, September 11-13, 2023.
    6. Brandstaeter S., Wirthl B., Nitzler J., Wall W. A.: Gaussian-process based global sensitivity analysis for complex models of active biomechanical systems, 5th International Conference on Uncertainty Quantification in Computational Science and Engineering (UNCECOMP 2023). Athens, Greece, June 12-14, 2023.
    7. Brandstaeter S., Fuchs S.L., Biehler J., Aydin R.C., Wall W.A., Cyron C.J.: Variance-Based Global Sensitivity Analysis of a Model of Aortic Growth and Remodelling. 9th GACM Colloquium on Computational Mechanics. Essen, Germany, September 21 - 23, 2022.
    8. Brandstaeter S., Fuchs S.L., Biehler J., Aydin R.C., Wall W.A., Cyron C.J.: Global sensitivity analysis of a homogenized constrained mixture model applied to aortic growth and remodeling. 92nd Annual Meeting of the International Association of Applied Mathematics and Mechanics. Aachen, Germany, August 15 - 19, 2022.
    9. Brandstaeter S., Fuchs S.L., Gizzi A., Aydin R.C., Cyron C.J. Gastric Peristalsis: a Computational Framework Based On Active-Strain Electromechanics. 14th World Congress in Computational Mechanics and ECCOMAS Congress 2020 (14th WCCM & ECCOMAS Congress 2020). Virtual congress, January 11 - 15, 2021.
    10. Brandstaeter S., Gizzi A., Fuchs S.L., Aydin R.C., Cyron C.J. Active-Strain Electromechanics of Gastric Tissue. 25th Congress of the European Society of Biomechanics (ESB 2019). Vienna, Austria, July 07 - 10, 2019. (Abstract)
    11. Brandstaeter S., Fuchs S.L., Gizzi A., Aydin R.C., Cyron C.J. Active-strain electromechanics for the computational modelling of gastric peristalsis. 90th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM 2019). Vienna, Austria, February 18 - 22, 2019. (Abstract)
Invited Talks
    1. Brandstaeter S., : Navigating Biological Variability in Biomechanical Models: Insights from Uncertainty Quantification and Global Sensitivity Analysis, invited, Gut Motility Workshop, Auckland, New Zealand, February 17 - 27, 2025

Teaching

Courses as lecturer

Full course:

 

Selected Chapters:

 

Guest lecturer:

  • Sensitivity Analysis for Biomechanical Models. hpc.bw Seminar Series: Computation & Data. Helmut Schmidt University, Hamburg, March 27, 2024
  • Uncertainty quantification in biomechanics. Mechanics of Biological Systems. University Campus Bio-Medico di Roma, December 11–12, 2023

 

Schools as lecturer

Labs

 

Supervised Student Theses

  1. Learning Admissible Parameter Spaces Of Computational Models, University of the Bundeswehr Munich, Germany (2024).
  2. Patient-Specific Modeling of Human Gastric Electromechanics, Hamburg Technical University (2023).

  3. Patient-specific reconstruction of the human stomach from medical imaging data, Hamburg Technical University (2022).

  4. Computational modeling of patient-specific gastric electromechanical, Technical University of Munich (2021).
  5. An electromechanics material model for the simulation of human gastric tissue, Technical University of Munich (2020).
  6. A Human Gastric Electromechanics Model with Realistic Geometry, Technical University of Munich (2019).
  7. Inverse Analysis of Biaxial Tensile Experiments for Soft Biological Tissue based on a Finite Element Model, Technical University of Munich (2018).
  8. Computational Modeling of Gastric Electromechanics, Technical University of Munich (2018).
  9. Experimental and Computational Analysis of the Constitutive Properties of the Stomach, Technical University of Munich (2017).
  10. Development of an Extended Gastric Electrophysiology Model, Technical University of Munich (2017).
  11. Identification of the Mechanical Properties of the Gastric Wall by Inverse Analysis of Biaxial Tensile Tests, Technical University of Munich (2017).

Scientific Community

Memberships

since 2024 Member International Association of Applied Mathematics and Mechanics (GAMM)
since 2023 Member International Association for Computational Mechanics (IACM)
since 2023 Member

German Association for Computational Mechanics (GACM)

Reviewing

I am pleased to contribute as a reviewer for the following international journals and publishers:

  • Advanced Modeling and Simulation in Engineering Sciences
  • Biomechanics and Modeling in Mechanobiology
  • Computer Methods in Applied Mechanics and Engineering
  • International Journal of Numerical Methods in Biomedical Engineering
  • International Journal for Numerical Methods in Engineering
  • Journal of Applied Mathematics and Mechanics
  • Proceedings in Applied Mathematics and Mechanics
  • Springer Nature Books

 

Member of Scientific Committees

I have been appointed as a member of the Scientific Committee for the following international conferences:

  • XI International Conference on Computational Bioengineering (ICCB 2025), 8-10 September, 2025, Rome, Italy

 

Organization of Minisymposia

I regularly co-organize minisymposia at international conferences. A comprehensive list can be found here:

  • Inverse Problems In Digital Twins: Optimal Design Of Experiments, Uncertainty Quantification and Real-World Applications, Second International Conference Math 2 Product (M2P 2025),  4–6 June 2025, Valencia, Spain, Co-organizers: Marco Mattuschka (German Aerospace Center), Max Von Danwitz (German Aerospace Center), Alexander Popp (University of the Bundeswehr Munich, German Aerospace Center)
  • Methodological Developments and Applications of Global Sensitivity Analysis in Science and Engineering, 6th International Conference on Uncertainty Quantification in Computational Science and Engineering, 15–18 June 2025,  Rhodes, Greece, Co-organizers: Gian Marco Melito (Graz University of Technology), Friederike Schäfer (Norwegian University of Science and Technology), Wouter Huberts (Eindhoven University of Technology)
  • Computational Mechanics of Active Biological Systems, 94th Annual Meeting of the International Association of Applied Mathematics and Mechanics, 18–22 March 2023, Magdeburg, Germany, Co-organizer: Lena Lambers (University of Stuttgart)

  • Current trends in modelling and simulation of biological systems:
    numerics, application and data integration    , 10th GACM Colloquium on Computational Mechanics for Young Scientists from Academia and Industry, Sept. 10–13 September 2023, Vienna, Austria, Co-organizer: Christian Bleiler (University of Stuttgart), Lena Lambers (University of Stuttgart), Renate Sachse (Technical University of Munich)